To study the function of H3K9 methylation in melanoma, we used the miniCoopR system (Ceol et al., 2011) to overexpress wild-type H3.3 and H3.3K9M in Tg(mitfa:BRAF(V600E)); tp53zdf1/zdf1; mitfaw2/w2 zebrafish (Figure 1A). Here, MITF is linked to melanoma.