The genes obtained from the KEGG database included a substantial number of genes involved in glioma, pathways in cancer, as well as Wnt, p53, JAK-STAT Notch, apoptosis, RAS, MAPK, mTOR and PI3K-Akt signaling pathways (Figures 7A,B, Supplementary Figure S9). Here, TP53 is linked to central nervous system cancer.