For example, the transcription factor SRY-related HMG-box 7 (Sox7), which acts as a tumor suppressor, has been found to be downregulated in a variety of cancers including GBM and its downregulation has been associated with poor prognosis (Katoh, 2002; Stovall et al., 2013; Liu et al., 2014; Zhao et al., 2016; Oh et al., 2017; Kim et al., 2018). The gene discussed is SOX7; the disease is cancer.