Angiogenesis has been demonstrated to be activated within 4–7 days after cerebral ischemia and contribute to neuronal remodeling and functional recovery via first providing guidance to the sprouting axons through VEGF signaling and second enhancing proliferation, migration and differentiation of neural stem/progenitor cells (Wang et al., 2007; Ruan et al., 2015; Kanazawa et al., 2017; Hatakeyama et al., 2020). The gene discussed is VEGFA; the disease is brain ischemia.