In contrast, Hypoxia inducible factor 1 (HIF-1), a key regulator of hypoxia, has been demonstrated to promote the migratory and invasive behavior of glioma cells as well as to induce angiogenesis by regulating the expression of VEGF, PDGFs and PDGFRs (Mendez et al., 2010; Peng et al., 2021). The gene discussed is VEGFA; the disease is central nervous system cancer.