IL27 and rheumatoid arthritis: All these cytokines/chemokines, like IL27, are considered arthritogenic factors and are up-regulated in Rheumatoid arthritis patients as well as CHIKV-infected patients, and had been associated with the development of inflammation and joint pain (González-álvaro et al., 2006; Wong et al., 2010; Adamopoulos et al., 2013; Burska et al., 2014; Yap et al., 2018; Kim et al., 2019).