Furthermore, Cavalcanti et al., 2019 reported that in patients with chronic symptoms of CHIKF, a significant and positive correlation between IL27 serum levels and tender joints was observed, suggesting a pathogenic role of IL27 in chronic CHIKV-infected patients and a possible role of IL27 in the pathogenesis of CHIKV-dependent arthralgia and arthritis. This evidence concerns the gene IL27 and Arthralgia.