To explore the detailed genetic and epigenetic differences between LCSL cells and other EpCAM-stained cells in both tumor and paratumor tissues, we developed a spatial multiomics method combining immunohistochemistry (IHC), laser capture microdissection (LCM) and genome sequencing with ultra-low-input cells (CIL-seq) (Figure 2A, Materials and Methods). The gene discussed is EPCAM; the disease is neoplasm.