Although the exact mechanisms remain unknown, evidence suggests that erastin induction downregulates the translocation of nuclear factor erythroid 2-related factor 2 (NRF2) within the nucleus in lung cancer and GCH1 is one of the downstream genes of NRF2 in skin cells (Xue et al., 2017; Gai et al., 2020). Here, NFE2L2 is linked to lung cancer.