Zhang et al. (2020c) used two m6A readers, YTHDC2 and IGF2BP3, to construct a prognostic model in CRC. Jiang et al. (2021) found that an m6A-related lncRNA-based signature was associated with tumor-infiltrating immune cells. Chong et al. (2021) used a similar method to ours to construct an m6Ascore, but their study was confined to colon cancer and used fewer cohorts. These studies support our result of a close link between m6A and immune TME. Here, IGF2BP3 is linked to malignant colon neoplasm.