For example, the tumor-associated macrophages (TAMs) in the TME are the main source of cytokine secretion, among which M1 macrophages express high levels of pro-inflammatory factors TNF-α, IL-1, IL-6, IL-12, or IL -23, along with the M2 phenotype, as the main body of TAMs, expressing anti-inflammatory cytokine IL-10, scavenger receptor A, and arginase, thus promoting tumor angiogenesis, invasion, metastasis, and tissue remodeling (Condeelis and Pollard, 2006; Mantovani et al., 2008; Sica et al., 2008). Here, TNF is linked to neoplasm.