BCR and cancer: For TME analysis, we observed that between BCR and no BCR groups, cancer-related fibroblasts, macrophages, stromal score, immune score, estimate score, and tumor purity were differentially expressed and were risk factors for BCR (HRs were 2.17, 1.79, 2.20, 1.93, 1.92, and 0.52 for cancer-related fibroblasts, macrophages, stromal score, immune score, estimate score, and tumor purity, respectively; Figure 5G).