STING1 and myocardial infarction: After MI, the inhibition of IFNAR and IRF3 in mice attenuated ventricular dilation, improved left ventricular dysfunction and survival (King et al., 2017) Supporting its role in pathophysiological involvement in cardiac diseases, Li et al. reported that knockout of STING in mice treated with LPS (mimicking sepsis-induced cardiomyopathy) improved survival rate and cardiac function.