In a different context, the involvement of mtDNA signaling in pathogenesis of Alzheimer’s disease (AD) is also currently under discussion, as several reports of mitochondrial dysfunction and also the dysfunction of Pink1/Parkin, excessive ROS production are reported in association with AD (Witte et al., 2009; Ye et al., 2015). This evidence concerns the gene PRKN and early-onset autosomal dominant Alzheimer disease.