There is also an E-cadherin-integrin crosstalk that govern the migratory capacity of cells, such as cancer cells (Canel et al., 2013), since the formation of an adhesome (Horton et al., 2015, Horton et al., 2016) may alter the E-cadherin-dependent cell-cell interaction and subsequently cellular locomotion. This evidence concerns the gene CDH1 and cancer.