Downregulation of EphB2 expression promoted the progression of CRC (Batlle et al., 2005; Oshima et al., 2008; Noberini and Pasquale, 2009) and was associated with more advanced CRC, poorer differentiation, poorer overall survival and disease-free survival (Jubb et al., 2005; Guo et al., 2006). The gene discussed is EPHB2; the disease is colorectal carcinoma.