EPHB2 and cholangiocarcinoma: EphB2 expression was reported to be upregulated and significantly associated with cancer progression and stage malignancy in the cervical cancer (CC) (Narayan et al., 2007; Gao et al., 2014), and the overexpression of EphB2 induced CC cells to undergo epithelial-mesenchymal transition (EMT) and acquire stem cell-like properties by activating the R-RAS pathway (Gao et al., 2014).