BDNF and neoplasm: As indicated in other types of cancers, neurotrophins may be secreted by neurons, mesenchyme or tumor cells, contributing to neurogenesis and further tumor survival or invasion; Adhesion molecules may serve as the “glue” between cancer cell and nerve to potentiate neural invasion; MMPs released by tumor cells help to degrade extracellular connective tissues, facilitating protrusion into the neural sheath; chemotaxis recruit other components and establish a favorable niche for neural tracking.