Transcription of L1CAM mRNA was significantly active in the invasive front compared to the center of tumor especially in patients with nodal involvement; besides, expression levels of L1CAM and ERK1/2 in CRC tissue is associated with lymph node metastasis, indicating supportive role of L1CAM-associated in CRC dissemination (Kajiwara et al., 2011; Fang et al., 2020). Here, L1CAM is linked to neoplasm.