Additionally, the analysis of immune-related genes showed that almost all genes related to antigen presentation and immune activation were enriched in the MHC-H group of both the ICI-cohort and the TCGA-BLCA cohort, especially those related to cross talk between immune cells (IFNG, CXCL9 and CXCL10) as well as ICIs therapy (LAG3, IDO1, CD70 and CD274) (log FC > 2, P < 0.05, Figure 4L). This evidence concerns the gene CD274 and bladder transitional cell carcinoma.