CD4 and bladder transitional cell carcinoma: Besides, MHC-H tumors were significantly associated with upregulated expression of genes related to activated dendritic cells (CCNA1 and CLEC4C), activated CD4+ T cells (CCL4 and CCL5), and activated CD8+ T cells (GNLY, GZMH and NKG7) in both the ICI-cohort and the TCGA-BLCA cohort (logFC > 1, all P < 0.01, Figure 4K).