In the AD group, all cortical ROIs revealed average SUVR values over 1.19, especially in significant brain areas of the medial temporal lobe, posterior cingulate and precuneus, parietal lobe, lateral temporal, frontal lobe, and occipital lobes associated with tau deposition (Braak and Braak, 1997). The gene discussed is MAPT; the disease is Alzheimer disease.