RNA interference can be used to silence specific genes linked to protect against hearing loss, particularly for gain-of-function mutations—for instance, GJB2, encoding gap-junctional protein connexin-26 (Cx26), is responsible for the majority of genetic hearing loss in the connexin gene family, particularly non-syndromic hearing loss in most populations (Wingard and Zhao, 2015). The gene discussed is GJB2; the disease is hearing loss disorder.