Studies have shown two members of the CLIC protein family, CLIC1 and CLIC4, to be significantly upregulated in EOC patients compared to healthy controls (Tang et al., 2012; Tang et al., 2013; Ye et al., 2015; Singha et al., 2018; Yu et al., 2018), and shed into the blood of ovarian cancer patients (Tang et al., 2012; Tang et al., 2013). This evidence concerns the gene CLIC4 and ovarian carcinoma.