It is also not useful for early diagnosis as CA-125 expression levels are too low for accurate detection and there are also several other conditions including endometriosis (Nisenblat et al., 2016), gall bladder (Wang, 2014) and liver cancer (Devarbhavi et al., 2002) where CA-125 levels are elevated, leading to false positive results. This evidence concerns the gene MUC16 and liver cancer.