We recently reported enhanced safety and efficacy of nanoliposomes functionalized with transferrin, which aids in receptor-mediated endocytosis across the BBB and targeting to glioma cells via the expression of transferrin receptors on the surfaces of both endothelial and glioma cells, in the delivery of combination anti-cancer therapies to murine models of gliomas (Lam et al., 2018). Here, TF is linked to central nervous system cancer.