Meanwhile, paradoxical effects such as sarcoidosis and other granulomatous disorders like rheumatoid nodules and vasculitis, paradoxical psoriasis and psoriasiform lesions, uveitis and other eye diseases, and miscellaneous auto-immune diseases like central and peripheral nervous system demyelinating disorders, have also been reported to be associated with anti-TNF drug use (95). The gene discussed is TNF; the disease is psoriasis.