Recent advances in the pathophysiologic understanding of COVID-19 suggests that CRS has a great association with the severity of disease due to increased serum levels of tumor necrosis factor α (TNF-α), granulocyte-colony stimulating factor (G-CSF), interferon gamma-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1α (MIP1A) (4, 6). This evidence concerns the gene TNF and COVID-19.