STX2 and infection: The humanized TMA-15 was tested in postinfection experiments to prevent Stx2 binding to the B subunit, protecting mice from a lethal challenge with STEC when given within 24 h of infection, as well as able to reduce brain lesions and death in a gnotobiotic piglet model (Yamagami et al., 2001; Kimura et al., 2002; Moxley et al., 2017).