LEE-negative STEC strains may also produce severe disease since other adhesins may be involved in adhesion/colonization of this subset of bacteria to enterocytes (McWilliams and Torres, 2014) and from the unusual HUS-inducing E. coli strain EAEC of serotype O104:H4 bearing stx2 gene, which was responsible for the major outbreak in Germany and parts of Europe in 2011 (Bielaszewska et al., 2011; Mellmann et al., 2011). The gene discussed is STX2; the disease is hemolytic-uremic syndrome.