TLR2 and cancer: Additionally, TLR gene polymorphisms may contribute to cancer susceptibility: TLR2 del allele is significantly associated with cervical cancer susceptibility and TLR2 ins/del genotype is strongly associated with tobacco usage in women with cervical cancer, while TLR4 Thr/Ile genotype was significantly associated with the early stage of cervical cancer in North Indian women (Pandey et al., 2009).