NFKB1 and endothelial dysfunction: Especially in case of oxLDL, adverse effects are well documented and include endothelial cell death by activation of NF-κB and activator protein-1 (AP-1) pathways (Valente et al., 2014) or endothelial dysfunction alongside ROS generation and nitric oxide (NO) synthesis inhibition (Mango et al., 2011).