When scored at ZT0 Bmal1+/+ controls show significantly lower colitis than Bmal1-/- mutants particularly in stool consistency (diarrhea) (Figure 5A) and fecal blood (Figure 5B), leading to increased total disease severity (Figure 5C) despite having no differences in weight loss (Supplementary Figure 2A). This evidence concerns the gene BMAL1 and colitis.