NOS1 and neurodegenerative disease: The PDZ family of proteins is one of the largest in the human proteome including membrane-associated guanylate kinases (MAGUKs), involved in different molecular signal networks (4); nitric oxide synthase 1 (neuronal) (NOS1), engaged in neurotoxicity associated with neurodegenerative diseases (5); segment polarity protein dishevelled homolog DVL1-2-3 (DVL1-2-3), implicated in cell proliferation and molecular transducer for different human diseases (6).