The upregulation of SPINK5 expression combined with the expression of nuclear receptor subfamily 0 group B member 1 (NR0B1), retinoic acid early transcription-1 (RAET1E), and secreted phosphoprotein 1 (SPP1) is associated with liver cancer vascular invasion, histological grade, clinical stage, and T stage, suggesting that the poor prognosis of liver cancer is associated with an immunosuppressive tumor microenvironment (146). This evidence concerns the gene SPP1 and neoplasm.