(192) used an adenoviral vector (Ad-SPINK7) as a biological treatment tool and found that Ad-SPINK7 can inhibit the invasion and adhesion of HCC cells at a low titer and change the expression of NF-κB, MMP2 and E-cadherin to reverse the malignant tumor phenotype. The gene discussed is SPINK7; the disease is hepatocellular carcinoma.