SPINK7, also known as esophageal cancer-related gene 2 (ECRG2), is expressed in the fetal skin, thymus, esophagus, oral epithelium, thyroid, brain, lung, heart, stomach, liver, spleen, colon, kidney, testis, muscle, gallbladder and adult esophageal mucosa, while SPINK7 is significantly downregulated in primary esophageal cancer tissue (167). Here, SPINK7 is linked to esophageal cancer.