The potency of emvododstat to promote cytotoxicity and differentiation of myeloid cells relative to that of the DHODH inhibitors brequinar and teriflunomide was evaluated using the primary cell cultures derived from the second set of 5 AML subjects (AML293, AML294, AML295, AML299, and AML303; see Table 1B). The gene discussed is DHODH; the disease is acute myeloid leukemia.