Our analysis also revealed that 11 (34.4%) out of 32 CRC patients positively tested for MMR genes have been shown to harbor germline MLH1 PVs, other 11 (34.4%) subjects carried germline MSH2 LPVs/PVs, 8 (25%) were carriers of germline PMS2 PVs, and 2 (6.2%) individuals showed germline MSH6 PVs (Figure 2 and Table 2). This evidence concerns the gene MSH2 and colorectal carcinoma.