MRC1 and colorectal carcinoma: Overall, considering 32 germline MMR-positive CRC probands, the highest number of LS diagnoses comes from the cluster of CRC patients selected by revised Bethesda guidelines (18/32; 56.3%), secondly from the subgroup of individuals fulfilling Amsterdam criteria II (9/32; 28.1%), and, to a lesser extent, from subset of tissue MMR-deficient (dMMR) subjects (5/32; 15.6%).