found a different result of the NLRP3 inflammasome in HCC: on the one hand, the NLPR3 expression was downregulated in HCC tissues compared to non-cancerous liver tissues, and its expression was negatively correlated with the pathological grade and clinical stage of HCC (19); on the other hand, in the comparison of normal liver tissue and liver cancer tissue, NLRP3 expression in normal liver tissue was low, while that in cancer tissues was upregulated. The gene discussed is NLRP3; the disease is hepatocellular carcinoma.