NLRP3 and liver cancer: found a different result of the NLRP3 inflammasome in HCC: on the one hand, the NLPR3 expression was downregulated in HCC tissues compared to non-cancerous liver tissues, and its expression was negatively correlated with the pathological grade and clinical stage of HCC (19); on the other hand, in the comparison of normal liver tissue and liver cancer tissue, NLRP3 expression in normal liver tissue was low, while that in cancer tissues was upregulated.