CCR2 and neoplasm: In other samples with a good prognosis, including TLS-positive samples and TLS-negative/MCPyV-positive samples, we observed upregulated expression of IDO1, IDO2, and CD27, and some chemokine genes, including CCR2, CXCR3, and CX3CR1, as well as PTPRC (encoding CD45) and MS4A1 (encoding CD20), which encode cell surface proteins of tumor-infiltrating lymphocytes (Figure 3B).