Among the 7 SNPs, LEPR rs1137101 showed a significantly decreased breast cancer risk under the dominant genetic model (GA + AA vs. GG, adjusted OR = 0.722, 95% CI = 0.584–0.893, p = 0.003) and co-dominant genetic model (GA vs. GG, adjusted OR = 0.719, 95% CI = 0.578–0.894, p = 0.003). Here, LEPR is linked to breast cancer.