ARF6 and breast carcinoma: On the other hand, a recent study showed that sevoflurane, especially at high concentrations, inhibits the migration, invasion, and epithelial–mesenchymal transition (EMT) of breast cancer cells, mediated by the upregulation of micro-RNA (miR)-139-5p and down-regulation of adenosine diphosphate–ribosylation factor 6 (ARF6) due to miR-139-5p–ARF6 binding in vitro (26).