Moreover, circ-SHPRH harbors potential binding sites for RBPs (U2AF65, EIF4A3, UPF1), and miRNAs (miR-1283, miR-4310, miR-182-3p, miR-888-3p, miR-4502, miR-6811-5p, miR-6511b-5p, and miR-1972), and may act as a sponge and regulate the progression of HCC (90). This evidence concerns the gene SHPRH and hepatocellular carcinoma.