AFP and Cirrhosis: In a stratified analysis (Figures 1B–V), the downregulation of DDX60L expression correlated with poor prognosis in HCC patients with non-metastasis (P = 0.013), age ≥55 (P = 0.009), tumor size <5 cm (P = 0.009), Edmondson grade = I–II (P = 0.042), microvascular invasion (P = 0.003), non-cirrhosis (P = 0.038), HBV positive (P = 0.017), tumor stages III–IV (P = 0.007), AFP >20 μg/L (P = 0.015), and multiple tumor (P = 0.009).