SLC1A5 enhances the uptake of Gln in the tumor microenvironment, which in turn enhances cell proliferation and migration by increasing phosphorylation of the mTOR complex 1 signaling axis; subsequently, overexpression of SLC1A5 is found to be relevant to patient prognosis and can act as a separate prognostic factor in patients with lymph node metastases combining with clinical information (39–42). This evidence concerns the gene SLC1A5 and neoplasm.