The observed reduction of these miRs along with tumor progression in the high-risk patients, the linearity study showing an inverse correlation with the expression of PD-Ls and the presence of binding sites on the target genes suggest that the miR100-5p and miR-138-5p might play a central role in the regulation of the expression of both TERT and immune checkpoint ligands. The gene discussed is TERT; the disease is neoplasm.