CDK4 and breast carcinoma: Randomized studies of adjuvant CDK4/6 inhibitors in early breast cancer have recently reported contrasting results, with abemaciclib reducing the risk of recurrence at 1-2 years for patients with node-positive, high-risk, ER-positive breast cancer in the MONARCH-E trial (45), and palbociclib failing to show benefit in the PALLAS (46) and PENELOPE (47) trials.