HOXB13 and neoplasm: These assays, which are performed on primary tumor tissue, include the immunohistochemical 4 (IHC4) protein test, 21-gene Recurrence Score (OncotypeDx), PAM50 intrinsic subtype (ProSigna ROR; risk of recurrence), 12-gene EndoPredict Score (EPClin), 70-gene signature (MammaPrint), and 2-component Breast Cancer Index (BCI; HOXB13:IL17BR).