ESR1 and triple-negative breast carcinoma: c-TRAK-TN (NCT03145961) evaluated immunotherapy in patients with triple negative breast cancer, DARE (NCT04567420) and LEADER (NCT03285412) are evaluating CDK4/6-inhibitors in ER+ disease, and ZEST (NCT04915755) is evaluating a PARP inhibitor in BRCA-related or triple negative breast cancer.