NR4A1 and breast cancer: The recurrence pattern from natural history studies of hormone-receptor positive (HR+) breast cancer demonstrates that the highest risk of relapse occurs in the first two years of follow-up, followed by a near constant annual relapse rate over the course of a lifetime (ranging up to approximately 2% per year in the highest risk patients), such that approximately 50% of the risk of recurrence for an individual woman is in the period beyond 5 years from diagnosis (2).