We detected no increase in TREM-1 expression in the peripheral blood or spleen of mice harboring RENCA tumors, but similar to 4T1 and EL-4, we found significantly higher levels of sTREM-1 in the blood of mice with RCC (Figure 5B) and confirmed the expression of Trem2 mRNA in RENCA tumors (Figure 5C). This evidence concerns the gene TREM2 and renal cell carcinoma.