Significant factors from the above calculations, cut off points of serum IL-18 (>132 pg/mL) and urine IL- 18 (>900.7 pg/mL) were included in the multiple logistic regression to assess the relationship of these factors to the incidence of AKI in preterm infants, showing that the ORadj of sIL-18 was 5.89 (95% CI:2.31–15.02), 4.15 (95%CI:1.58–10.89) for uIL-18 (, Table 3). The gene discussed is IL18; the disease is acute kidney injury.