CNR1 and alcohol dependence: GABAergic dysregulation in the CeA is a hallmark of the transition to alcohol dependence in animal models.101 A study by Varodayan and colleagues reported that activation of CB1 via WIN decreased the frequency of spontaneous and miniature CeA GABAA receptor-mediated IPSCs, which could be blocked by CB1 antagonism.55 Two weeks of CIE vapor significantly blunted this effect of WIN.