Regional dysfunction was identified in CB1, indicated by reduced relative CB1 binding, in the hippocampus and caudate-putamen of rats exposed to alcohol via liquid diet for 7 days.120 A 7-day alcohol paradigm reduced WIN sensitivity and induced altered monoamine synthesis in the locus coeruleus, hippocampus, and striatum.150 Additionally, genetic deletion of CB1 impaired the neuroadaptations of NMDA and GABAA receptors in the cerebral cortex and hippocampus induced by chronic ethanol treatment, indicating that the eCB system plays a critical role in alcohol dependence.151. The gene discussed is CNR1; the disease is alcohol dependence.