The eCB system in the BLA plays a role in gating stress and anxiety responses by modulating GABA and glutamate transmission.108,109 CB1 is highly expressed in cholecystokinin-positive GABAergic interneurons110,111 and at lower levels in glutamatergic pyramidal cells.111 A wide body of work has demonstrated that CB1 activity decreases GABAergic transmission in the BLA.110,112–114 GABAergic transmission in the BLA is increased by acute ethanol exposure in naïve rats via both presynaptic and postsynaptic mechanisms. The gene discussed is CNR1; the disease is Anxiety.