CNR1 and Anxiety: CB1 activation is known to decrease glutamate release in many brain areas, including the CeA, of male rodents.51,106 Glutamatergic transmission also was investigated in the CeA of Wistar and Marchigian Sardinian alcohol-preferring (msP) rats.107 Notably, msP rats display enhanced anxiety, stress, and alcohol drinking, simulating the alcohol-dependent phenotype.