CDH1 and metastatic malignant neoplasm in the lymph nodes: Similarly, previous studies have indicated the abnormal expression of cytoplasmic E-cadherin in various cancer tissues, which was strongly associated with more aggressive tumor-related variables, such as poor grade levels and lymph node metastasis of patients (Ramesh, Nash & McCulloch, 1999; Bendardaf et al., 2019; Gao et al., 2005).