Yokota et al. manifested the cell proliferation capability of sesamin in the breast cancer cell and found that sesamin inhibited cell proliferation through decreasing cyclin D1 gene expression that mediates cyclin D1 degradation with concomitant increasing retinoblastoma protein dephosphorylating, leading to growth inhibition at the dose of 1-100 μM [73]. Here, CCND1 is linked to breast carcinoma.