Sesamin is a type of phytoestrogen that belongs to lignans [60], associated with several pharmacological activities against breast cancer through regulating several receptors, like estrogen receptor-α (ER-α), receptor-β (ER-β), G protein-mediated signaling pathways, growth factor receptor, i.e., HER2 and EGFR, and some receptor tyrosine kinase (RTK). The gene discussed is ESR2; the disease is breast cancer.