MAPK8 and cancer: Macrophage-induced proangiogenic activities were inhibited by sesamin (50-100 μM) in breast cancer cell line through the underlying mechanism of inhibiting major transcription factors including HIF-1α and NF-κB and signaling mechanism of ERK, JNK, and PI3K and metastasis factors including VEGF and MMP-9 in MCF-7 and MDA-MB 231 cancer cell [78].