AGT and hypertrophy: As expected, compared with vehicle, epoxomicin markedly ameliorated Ang II-induced cardiac dysfunction, hypertrophy, and fibrosis in WT mice (as indicated by improvements in EF%, FS%, LVAW, LVPW, LVID, the E/A ratio, heart size, the HW/TL ratio, the cross-sectional area of CMs, and the fibrotic area) (Figures 8(a)–8(d), Table S3).