Consistent with our previous data related to pressure overload-induced cardiac remodeling [19], we and another group found that the levels of VEGF-C, VEGFR-3, and cardiac lymphangiogenesis are increased in the adaptive hypertrophy phase (Ang II infusion for 2 weeks) (Figure 1) and decreased in the HF phase (Ang II infusion for 6 weeks) [41], suggesting that VEGFR-3-dependent lymphangiogenesis may be important for the transition from Ang II-induced cardiac hypertrophy to HF. The gene discussed is FLT4; the disease is hydrops fetalis.