In conclusion, panel A including MMP-9/TIMP-1 in early stages demonstrated a higher diagnostic value for breast cancer than the rest of the panels, as it had OR = 6.87 and 95%CL (2.07-31.35) and exhibited noticeably higher accuracy than mammography as well as the highest sensitivity (97.5) among other panels and the highest specificity (95) after panel H (CA 15.3+IL-18). Here, TIMP1 is linked to breast cancer.