The results showed that urinary exosomal hsa_circ_0008925 could effectively distinguish renal fibrosis from no fibrosis, with the largest AUC of 0.782 (95% CI: 0.690-0.874; P < 0.001) higher than that of Scr (AUC of 0.625; 95% CI: 0.504-0.760; P = 0.055), BUN (AUC of 0.479; 95% CI: 0.351-0.606; P = 0.744), cystatin C (AUC of 0.606; 95% CI: 0.484-0.729; P = 0.103), eGFR (AUC of 0.612; 95% CI: 0.489-0.734; P = 0.087), and 24 h proteinuria (AUC of 0.555; 95% CI: 0.421-0.688; P = 0.403). The gene discussed is CST3; the disease is fibrosis.