The results indicated that OX40-Fc could improve arthritis while PD-1-Fc-aggravated arthritis in CIA mice; OX40-Fc could reduce the destruction of articular cartilage tissue structure and inflammatory cell infiltration, while PD-1-Fc could destroy the repair effect of OX40-Fc on RA mice. This evidence concerns the gene TNFRSF4 and rheumatoid arthritis.