Subgroup survival analysis indicated that DEFB1 mRNA overexpression significantly affected the overall survival outcome of OSCC tumor cases belonging to the subgroup of higher T stage T3/T4 (p = 0.046), M0 (p = 0.033), female (p = 0.036), age of >60 years old (p = 0.005), being smoker (p = 0.026), without having received radiation therapy (p = 0.005), primary therapy outcome showing PR and CR (p = 0.001), without lymphovascular invasion (p = 0.005), and with lymph node neck dissection (p = 0.026), respectively (Figure 3(d)). This evidence concerns the gene DEFB1 and neoplasm.