Research indicated that by prophylactic administration of YQHYJD, lung tissue injury of LPS-induced ARDS rats was alleviated, the levels of inflammatory cytokines IL-1β and IL-18 in blood serum were downregulated after the activation of the TLR4/NLRP3 pathway, the content levels of inflammatory proteins TLR4 and NLRP3 in BALF and lung tissue homogenate were reduced. This evidence concerns the gene IL1B and acute respiratory distress syndrome.