Ando et al. demonstrated that, in pancreatic cancer, by upregulating C-X-C motif chemokine 5 (CXCL5) and C-X-C-motif chemokine receptor-2 (CXCR2), cancer cells can enhance migration and invasion by inducing necroptosis [13]. This evidence concerns the gene CXCR2 and familial pancreatic carcinoma.