Previous GWAS have suggested a polygenic susceptibility to leukemia, identifying SNPs in different loci influencing leukemia risk such as, 7p12.2 (IKZF1), 9p21.3 (CDKN2A), 10p12.2 (PIP4K2A), 10q26.13 (LHPP), 12q23.1 (ELK3), 10p14 (GATA3), 10q21.2 (ARID5B), and 14q11.2 (CEBPE)8–12. The gene discussed is ARID5B; the disease is leukemia.