Previous GWAS have suggested a polygenic susceptibility to leukemia, identifying SNPs in different loci influencing leukemia risk such as, 7p12.2 (IKZF1), 9p21.3 (CDKN2A), 10p12.2 (PIP4K2A), 10q26.13 (LHPP), 12q23.1 (ELK3), 10p14 (GATA3), 10q21.2 (ARID5B), and 14q11.2 (CEBPE)8–12. This evidence concerns the gene CEBPE and leukemia.