Previous GWAS have suggested a polygenic susceptibility to leukemia, identifying SNPs in different loci influencing leukemia risk such as, 7p12.2 (IKZF1), 9p21.3 (CDKN2A), 10p12.2 (PIP4K2A), 10q26.13 (LHPP), 12q23.1 (ELK3), 10p14 (GATA3), 10q21.2 (ARID5B), and 14q11.2 (CEBPE)8–12. Here, PIP4K2A is linked to leukemia.