Also, adjusted linear regression analysis of a fitted model (F=4.212; p=0.017) for the relationship between zonulin with measures of obesity, inflammation and endothelial function showed reduced DBP and increased waist circumference to predict gut permeability (R2= 0.055, Adj.R2= 0.042; p<0.05) in the cohort. Here, HP is linked to obesity due to melanocortin 4 receptor deficiency.