Adjusted linear regression analysis of a fitted model (F=26.012; p<0.001) for the relationship between adiponectin with measures of obesity, gut permeability and endothelial function showed increased visceral fat to predict inflammation; that is, reduced adiponectin (R2= 0.15, Adj.R2= 0.145; p<0.001) in the cohort. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.