The SBSN protein expression level (2.71 ± .49 vs. 1.19 ± .20) and high-positive expression rate (18.52 vs. 0%) were significantly higher (p < .05) in the lymph node metastasis group than in the non-metastasis group, respectively. The gene discussed is SBSN; the disease is metastatic malignant neoplasm in the lymph nodes.