CD8A and neoplasm: Furthermore, patients with PTC with high SBSN expression levels showed lower scores in processes such as T cell activation and T cell recognition of tumor cells, which might be due to higher levels of iDCs and Tregs in their tissues, as DCs with an immature phenotype are usually unable to fully activate T cells (Yu et al., 2013) and Tregs also suppress the activation of CD8+ T cells (Jang et al., 2017).