As WD needs to identify the diseases, namely, Menkes disease, occipital horn syndrome (OHS), Indian childhood cirrhosis (ICC), and some other diseases and in specific subgroups defined by age, ethnicity, or clinical subgroups, our three parameters (elevated ALT, decreased CP level, and increased 24-h urinary copper level) may not be suitable (Lorincz, 2018; Ryan et al., 2019). This evidence concerns the gene GPT and occipital horn syndrome.